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PGD

Pre implantation genetic diagnosis (PGD) is an IVF procedure designed to examine your embryos for chromosomal abnormalities.

PGD- How is a diagnosis made?

Embryos are created by combining eggs and sperm in the laboratory. From each embryo, one or two blastomeres are removed and tested. If the embryo is judged to be free of the disorder, they are transferred to the uterine cavity.

Why is PGD performed?

Without PGD, embryos are chosen based only on their visual quality and morphology, which cannot distinguish chromosomally normal embryos from abnormal embryos. PGD aims at improving pregnancy and live birth rates by screening your embryos for chromosomal abnormalities.

What are the indications for PGD?

Indications for PGD are –

  • Advanced maternal age ( > 35 years)
  • Recurrent miscarriage
  • Repeated IVF/ICSI –ET failure cycles
  • Unexplained infertility
  • Male factor
  • Known genetic causes.

How does PGD help?

PGD will help the couples to identify embryos carrying a genetic disease or chromosomal abnormality, thus avoiding the difficult choice of abortion.

What does PGD involve?

Couples who undergo an IVF/ICSI cycle, where eggs and sperm are injected for fertilization, and from resultant embryos one or two blastomeres are removed to check the genetic abnormality. Blastomere biopsy is done at 6-8 cell embryos and then tested for any chromosomal abnormality.

After the biopsy the embryos are kept in culture media for further development till the result comes. Once the results are ready, the embryos which are free of genetic disease are transformed to the uterus.

How do we perform PGD?

An embryo biopsy is taken at D3 and chromosomes are examined in time for your embryo transfer. In future we will establish a new test for all the 46 chromosomes using a Multi color FISH probe kit which attach to the tips of the chromosomes instead of checking only for the usual 5 chromosomes.